الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Parasitic diseases continuous to cause significant morbidity and mortality throughout the world irrespective of the patient’s immune status
Risk factor for acquisition of parasitic infection are the same in both immunosuppressed and immune competentindividual . what the role of immune system in parasitic infection ?
Through local and systemic responses ,the immune system plays an integral part in modifying the establishment of infection, controlling disease once it is established ,limiting the severity and dissemination of the disease and assisting in clearance or control of the parasite . thus immunosuppressed host are more likely to acquire infection after exposure .have more severeinfection.have disseminated infection than localized ,and be unable to clear parasites with chronic carriage states ,furthermore with immune reconstitution through effective therapy or withdrawal of immunosuppressive agents ,these patients are more likely to like immunocompotent hosts.
In the present study, 100 stool samples were collected from child receiving chemotherapy attributed to inpatient Sohag Oncology Institute .and 100 stool samples from apparently healthy child as a control group .
The collected samples were examined macroscopically, by direct smear and Kato thick smear methods. Part of each sample was also preserved in formalin 10% for further testing. Other concentration techniques used were; simple sedimentation, simple floatation, formal ether sedimentation tests. Also all samples were stained by modified ZiehlNeelsen stain for detection of oocycts of coccidia. Results were tabulated and statistically analyzed.
The results revealed that the prevalence of intestinal parasitic infections was 94% in immunocompromised hosts and 35% in healthy normal control.
Cryptosporidium parvum was detected in 45% of immunocompromised child receiving chemotherapy (45 cases) and in 10% of healthy control group (10 cases) .The infection was considered of a significant value (p value < 0 .001).
G. lambliawas detected in 19% of immunocompromised child receiving chemotherapy (19 cases) and in 7% of healthy control group (7 cases) .The infection was considered of a significant value (p value < 0 .001).
E. histolytica was detected in 14% of immunocompromised child receiving chemotherapy (14 cases) and in 4% of healthy control group (4 cases) .The infection was considered of a significant value (p value < 0 .001).
E. coli was detected in 12% of immunocompromised child receiving chemotherapy (12 cases) and in 4% of healthy control group (10 cases). The infection was statistically non significant (p value=0.674).
H. nana was wasdetected in 4% of immunocompromised child receiving chemotherapy (4 cases) and in 4% of healthy control group (4 cases) The infection was statistically non significant (Pvalue=1.000).
Schistosomamansonia was wasdetected in 0% of immunocompromised child receiving chemotherapy (0 cases) and in 2 % of healthy control group (2 cases) The infection was statistically non significant (Pvalue=0.155).
As regards the diagnostic procedures used, the number of intestinal parasites in the samples detected by formol ether sedimentation method was 55 parasites, 45 parasites by simple sedimentation, 45 parasites by simple floatation, 40 parasites by Kato thick smear and lastly 47 parasites by direct smear. So, the best method for diagnosis of intestinal parasites in the present study was formol ether sedimentation technique.
In conclusion the present study highlight the Importance of testing for intestinal parasites in immunocompromised children and emphasizes the necessity awareness among clinicians regarding the occurrence of these parasites in this population and health education of the population for food hygiene . the frequency and the danger of those opportunistic infection require their efficient diagnosis and appropriate management.