الفهرس 
Allergic RhinitisOnly 14 pages are availabe for public view
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Abstract
Allergic rhinitis is a symptomatic disorder of the nose induced after allergen exposure due to an IgE-mediated inflammation of the membranes lining the nose. Mannan-binding lectin (MBL), a protein of the innate immune system coded for by the MBL2 gene, constitutes an important effector molecule of innate immunity in the serum. It binds allergens/antigens, activates the lectin complement pathway and modulates the levels of proinflammatory cytokines.
The current study involved 60 adult patients with allergic rhinitis and 30 healthy medically free control subjects. There was no statistically significant difference between patients and control as regard gender or age. When serum MBL level was compared between cases and controls, a high statistically significant difference was detected.
On comparing serum MBL level among various study parameters only statistically significant difference was detected between patients with mild AR and those with moderate to severe AR. Although there was a positive correlation between MBL serum level and age and duration of illness (yrs), there was no statistical significance as well as an inverse correlation with serum total IgE level.