الفهرس 
Recurrent Early Pregnancy Loss (Miscarriage)Only 14 pages are availabe for public view
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Abstract
Recurrent pregnancy loss (RPL) is defined as at least two or three sequential abortions before the 20th week of gestation. RPL occurs in 1% to 5% of all pregnancies.
This randomized clinical trial was conducted in the repeated miscarriage clinics in the Obstetrics and Gynecology Department, in Ain Shams University Hospital, Cairo, Egypt from January2015 till December 2015. 165 pregnant women, who fulfilled the inclusion criteria and after taking an informed consent, were recruited from outpatients’ clinic.
Patients were divided into two groups:
Study groups:
• group 1: This group included 82 pregnant females who administered low dose aspirin 75 mg tab. One tablet twice daily and prednisolone 5mg two tablets twice daily
• group 2: This group included 83 pregnant females as a control group who received specially manufactured tablets, resembling prednisolone and aspirin tablets in shape, color and size. These tablets were manufactured in our pharmacology department (placebo).
Both groups were followed in Ain shams recurrent miscarriage clinic every two weeks by ultrasonography from the incidence of the pregnancy till 20 weeks gestation.
In the current study, the mean age of the patients was (28.82±3.88) and they were in the age group of 19-35 years while the mean BMI was 29.09±2.67. The mean age in the control group was (29.46±4.81) and they were in the age group of 18-35 years while the mean BMI was 29.14±3.56 with no statistically significant difference between the two groups (P>0.05) as regards the age and BMI. As regards other clinic-demographic data of the participants, there was no significant difference between the two groups as regards parity, number of previous live birth, number of previous miscarriages, the duration of previous pregnancies,
Women who were treated with prednisolone (PSL) plus LDA had a 32.2% higher live birth rate than the control group and according to on-going pregnancy data was in case group 60/82 (73.2%) and in control group 34/83 (41%) OR (C.I. 95% 3.931 [2.040-7.573] RR (C.I. 95%1.786 [1.334-2.386] p <0.001 (HS), with a significant difference between the two groups.
As regards the occurrence of complications in both groups, there was no statistically significant difference between the two groups as regards bleeding in early pregnancy, pregnancy induced HTN, pre eclamptic toxemia, gestational DM, preterm labour, intrauterine fetal death, intrauterine growth retardation, thrombocytopenia, epistaxis, bleeding per gum, hematuria, DVT, GIT problem, Abruptio placentae (P> 0.05). There was a significant difference between the two groups as regards the development of bruising (P < 0.05).
This study demonstrates that combination treatment of prednisone and aspirin result in higher live birth rates than no treatment in women with idiopathic recurrent miscarriage.