الفهرس 
1. INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 136 |  |  |
| | | from | 136 | | |
Abstract
Hepatic fibrosis is an integral part in the progression of chronic liver disease, finally leading to cirrhosis and hepatocellular carcinoma. chronic liver disease and cirrhosis are important causes of morbidity and mortality in the world. The present study is an attempt to reveal the preventive effect of Mango (Mangifera indica L.) seed kernel extract (SKE) and peel extract (PE) against rat induced liver fibrosis by thioacetamide (TAA). TAA administration caused liver fibrosis by increasing oxidative stress that causes increased membrane lipid peroxidation (LPO) and decreased cellular antioxidant stores which facilitate progression of fibrosis. Treatment with different mango extracts pre, during and after TAA administration decreased MDA levels and also decrease cyclooxygenase-2 (COX-2) and nuclear factor-kabba b(NF-KB) expression in rat liver tissues. These treatments also decrease platelet derived growth factor-bb (PDGF-BB) and tumor necrosis factor-α(TNF-α) level in rat liver tissues. However these treatments increased the activities of catalase and superoxide dismutase (SOD) in liver tissues. We concluded that these extracts have an important role in the treatment of liver fibrosis through its potent antioxidant, antiproliferative, antifibrogenic and antiinflammatory effects. Also the effect of administration of SKE and PE separately for 11 weeks on healthy rats was studied.