الفهرس 
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Abstract
OME is primarily a chronic inflammatory condition and the causes
of inflammation are multifactorial. But much controversy remains regarding its pathogenesis. An increasing weight of clinical evidence suggests that the role of allergy in development of OME.
This study is designed in an attempt to identify any possible etiological relationship between allergy diagnosed by IgE and OME in children.
This study was carried out in the period from March,2015 and October,2015 in ENT department ,Menoufia university hospital and ENT department ,Benha teaching hospital
This study was done using 80 cases, 60 patients diagnosed as chronic otitis media with effusion (resistant to medical treatment or recurrent after successful medical treatment) ).Patients were subjected to myringotomy with insertion of tympanostomy tube (grommet tube),with mean age 7.8 years and 20 control children children diagnosed as acute otitis media with effusion with impending TM perforation not responding to medical treatment for 48 hours undergone tympanocentesis. with mean age 6.7 years.
Level of total IgE in the serum was assayed in patients and control groups as well as in the MEE of patients and control groups.
Data showed that, the total IgE in the serum of the patients was 26.4-712.4 IU/mL with mean value 254.3 IU/mL While IgE in the serum of control sample was 29.6–147.2 IU/mL with mean value 70.7 IU/mL. The total IgE level in normal, (allergy-free adults) is less than 190 IU/mL in the serum. This means that, there is evidence of allergic etiology in patients who suffer from secretory otitis media, as results showed that, there is a correlation between total IgE in serum and total IgE in MEE in the patients group as P = .001 also the serum level of total IgE is higher in the serum of patient’s group than control group.
We can support the role of allergy diagnosed by total IgE in serum and in MEE in etiology of COME.