الفهرس 
Anatomic & Physiologic ConsiderationsOnly 14 pages are availabe for public view
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Abstract
This is a pilot study conducted in the Early Cancer Detection Unit of the Ain Shams University Maternity and Women’s Hospital, Abbasseyah – Cairo, Egypt in the period from November 2015 to June 2016. It included twenty patients who were scheduled for abdominal hysterectomy and bilateral salpingo-oophorectomy for a benign gynecological indication.
The patients participating in the study were subjected to hysteroscopic tubal cannulation at the uterotubal junction with unilateral instillation of 0.5 ml. of an adhesive material: Isoamyl 2 cyanoacrylate (Amcrylate®). These patients were randomly allocated and scheduled to abdominal hysterectomy and bilateral salpingo-oophorectomy according to the sealed opaque envelope method to 4 groups, each of 5 patients: group A were scheduled one week after the procedure, group B were scheduled after a 2 week-interval, group C after 3 weeks and group D after 4 weeks post procedure.
The aim of the study was to test the safety of the material and its effectiveness on effecting tubal occlusion.
The material used proved to be safe as evidenced by clinical, laboratory and histopathological findings. The procedure was relatively easy to perform and learn. There was minimal discomfort to the patients and no patients asked to interrupt the procedure for any reason.
The procedure was 85% effective if we take into consideration a negative methylene blue testing. However, from a histopathological point of view, only 30% of the cases were completely occluded at the time of their respective assessment.
The small number of patients participating in the study and the presence of concomitant pathological lesions in this series might have hindered the proper cannulation of the tube in some cases with subsequent effection of the effectiveness of the procedure.
We do recommend the performance of a larger study with patients having different intracavitary pathologic lesions and extending over longer period of time to properly asses the histopathologic changes, possible side effects and effectiveness in effecting tubal obstruction and to explore the possibility of applying this rather simple technique to cases of hydrosalpinx before artificial reproductive technology procedures. Furthermore, a cost analysis should accompany the recommended study.