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Abstract Background: Postmenopausal bleeding: is a term of vaginal bleeding occurring after twelve months of amenorrhea, in a woman of the age where the menopause can be happened. Transvaginal ultrasound scan (TVUS): is the best non invasive, first-line procedure to identify which women with PMB are at higher risk of endometrial tumor. Aim of the Work: To study the sensitivity of MRI in comparison to Transvaginal ultrasonography in differentiation of underlying causes of postmenopausal bleeding. Methodology: The study including 40 female patients with age ranged from 50-65 years old (mean age 55±10.28) complaining of postmenopausal bleeding referred from the gynaecological clinic to the Radiology department.The study was conducted in the Ain Shams hospital during a period from January 2015 to May 2016. Results: The study included 40 female patients with age range from 50-65 years (mean age 55±10.28) who complained of postmenopausal bleeding referred from the gynaecological clinic to the Radiology department in Ain Shams hospital during a period from January 2015 to May 2016. Conclusion: This large prospective implementation study shows: TVUS is a useful method for screening for endometrial abnormalities and we recommend its use in women with postmenopausal bleeding. Hence, unnecessary operations in postmenopausal women could be spared where the endometrium is ultrasonographically normal. While MRI is the superior diagnostic method to detect the myometrial invasion and cervical invasion. In other words, MRI can diagnose endometrial cancer in the early stage and may be a useful tool to guide the surgical approach, avoiding overtreating low-risk. |