الفهرس 
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Abstract
Two hundred samples from 50 whole broiler chickens (30 frozen and 20 fresh) represented by breast, thigh, liver and kidney samples (50 of each) were collected from Minofia governorate for detection their residual level of oxytetracycline (OTC) and sulfamethazine (SMZ). The detection and estimation of such antimicrobial were applied by FPT& HPLC. Then some of positive samples were cooked for detection of such antimicrobial residues. The result showed that in total the positive samples of FPT were 14%, 20%, 28% and 36% for OTC residues while 10%, 12%, 16% and 20% for SMZ residues for each sample of breast, thigh, liver and kidney respectively. The average concentration of OTC by HPLC in positive frozen samples by (mg/kg) were (0.198 ± 0.032), (0.348± 0.0617), (1.423 ± 0.303) and (1.932 ± 0.316) while in SMZ were (0.2625 ± 0.060), (0.427± 0.097), (0.686±0.1225) and (1.410 ± 0.275) for breast, thigh, liver and kidney respectively. Accurately, 3.33%, 13.33, 16.67% & 26.67% of the examined samples for OTC and 6.67%, 10%, 13.33% & 16.67% of the examined samples for SMZ were unaccepted for breast, thigh, liver and kidney respectively. The average concentration of OTC by HPLC in positive fresh samples by (mg/kg) were (0.417 ± 0.087), (0.665 ± 0.231), (2.07 ± 0.343) and (2.643 ± 0.597) while in SMZ were (0.370 ± 0.090), (0. 5234 ± 0.13), (1.268 ± 0.226) and (2.0525 ± 0.333) for breast, thigh, liver and kidney respectively. Accurately, 15%, 20%, 30% and 35% of the examined samples for OTC and 15%, 15%, 20% and 25% of the examined samples for SMZ were unaccepted for breast, thigh, liver and kidney respectively. Cooking process has reduced effect on SMZ also on OTC, but in OTC give degradation product have more toxic effect than the parent drug.