الفهرس 
ch1Only 14 pages are availabe for public view
 |  | from | 259 |  |  |
| | | from | 259 | | |
Abstract
Summary
The thesis includes two parts:
Part I: The uses of 2-ethoxy (4H)-3,1-benzoxazin-4-one in the synthesis of quinazolinones
• Reaction of 2-ethoxy (4H)-3,1-benzoxazin-4-one (1) with 2aminoethanol in ethanol followed by heating to give at first the open structure 2-ethoxycarbonylamino(βhydroxyethyl)benzamide (2) then 2-ethoxy–3-(2hydroxyethyl)quinazolin–4–one (3) respectively. • Reaction of compound (1) with p-toluidine, p-anisidine, phydroxyaniline, o-hydroxyaniline and o-bromoaniline in boiling ethanol then further heating of products to give first the open structures anthranils (4a-e) then the novel quinazolinones (5a-e). • Reactions of compound (1) with p-aminobenzoic acid, 2aminonicotinic acid, p-phenylenediamine and o-tolidine in butanol and/or ethanol affording compounds (6a-d) respectively. • Reaction of compound (1) with o-phenylenediamine in ethanol yielded compound (7). i
• Reaction of compound (1) with glucosamine hydrochloride in pyridine afforded compound (8). • Reaction of compound (1) with o-naphthalenesulfonyl hydrazide in ethanol yielded compound (9). • Reaction of compound (1) with n-decanohydrazide in ethanol afforded compound (10). • Interaction of compound (1) with benzoylhydrazine in nbutanol yielded compound (11) and in benzene afforded compound (12).
• Reaction of compound (1) with semicarbazide in acetic acid/fused sodium acetate gave compound (13). • Reactions of compound (1) with amino acids namely, DLalanine, L-asparagine, and L-arginine in pyridine yielded compounds (14a-c) and with L-cysteine in pyridine gave compound (15). • Reactions of compound (1) with heteroaromatic amines namely, 2-phenyl-5-aminothiadiazole, 2-cinnamyl-5aminothiadiazole and 5-phthalimido-methyl-2aminothiadiazole in acetic acid yielded compounds (16a-c), respectively.
ii
• Reactions of compounds (16a-c) with formamide afforded compounds (17a-c). • Reaction of compound (1) with hydrazine hydrate in ethanol yielded compound (18).
• Reaction of compound (18) with chloroacetyl chloride in DMF yielded compound (19).
• Reaction of compound (19) with ammonium acetate in oil bath gave compound (20). • Reaction of compound (1) with ammonium acetate in oil bath yielded compound (21).