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Abstract Basal-cell carcinomas make up 80% of all skin cancers and are the most common malignant disease in white populations [256]. The incidence of basal-cell carcinoma is increasing worldwide up to 10% per year, and is also increasing in young people [257]. Basal cell carcinoma is locally invasive, with slowly spreading growth which rarely metastasize, arising in the epidermis or hair follicles and in which, in particular, the peripheral cells usually simulate the basal cells of the epidermis [257]. BCCs occurs most frequently at sun-exposed sites, with the head and neck being the common areas and more precisely develops on the face with the nose and lip most commonly affected [235]. CXCR4 is a rhodopsin-like seven-transmembrane G-protein coupled receptor that exclusively binds to CXCL12 [258]. CXCL12–CXCR4 axis plays an important role in multiple biological processes[259] and is also involved in cancers and in organ-specific metastasis. Therefore, the receptor can represent a valuable therapeutic target for multiple diseases such as inflammation, cancer, and HIV/AIDS [260]. β. |