الفهرس 
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Abstract
The present thesis comprises the following chapters:
chapter 1 : An introduction describing bronchial asthma and chronic obstructive pulmonary disease, phosphodiesterase IV as a potential approch for the treatment of inflammatory diseas
chapter2 :our strategy on designing tetrahydro-b-carbolines as potentials discussion for synthetic pathways
chapter 3 :A correlation between the chemical structureof novel compounds and obtained biological activities molecular.
chapter 4: the present investigation involves the synthesis of 11 intermediates.