الفهرس 
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Abstract
The present study aimed to investigate the nutrion, hypoglycemic,
hypolipidemic and immunomodulatory effects of different concentrations
(0.5 and 1.0%) of the brown seaweed Fucus vesiculosuss which grown in
Egyptian Red Sea coasts. Forty two adult male albino rats were weighing
(150 ± 10 gm per each) used for these investigations. All rats were fed on
basal diet for one week before starting the experiment for acclimatization.
After one week, rats were divided into seven groups, (each with 6 rats)
according to the following scheme for Successive 42 days: group (1):
control negative was fed on basal diet. group (2): served as
hyperglycemic induced by Alloxan and it sub-divided into three groups:
The A group: control positive hyperglycemic rats fed on basal diet. The
B and C groups: hyperglycemic rats fed on basal diet supplemented with
0.50% and 1% of F. vesiculosuss respectively. group (3) served as
Hyperlipidemic rats induced by hyperlipidemic diet (formulated basal diet
with (1%) cholesterol and (0.25%) bile salts) and it sub-divided into three
groups: The D group: control positive Hyperlipidemic rats fed on
hyperlipidemic diet. The E and F groups: Hyperlipidemic rats fed on
hyperlipidemic diet supplemented with 0.50% and 1% of F. vesiculosuss
respectively. At the end of experiment, rats were scarified and blood
samples were collected for biochemical analysis. While, rats organs
(liver, kidneys and spleen) were carefully removed for histopathologically
examination.
The obtained results revealed that F. vesiculosuss supplementation has
significant action in reduction of body weight gain in both control group
and hyperlipidemic groups. Whereas, no significant in reduction of body
weight gain of diabetic groups. Also, results indicated that
supplementation with F. vesiculosuss induced a significant reduction in
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blood glucose and lipid profiles in of both of diabetic rats and
hyperlipidemic as well as the control group. Results indicated that,
supplementation with F. vesiculosuss has significant improves in
immunity profile in all groups. Whereas, no significant in hemoglobin
level. While regarding to the liver and kidney functions, no significant
improves in all groups. Whereas, there was significant improves in liver
functions in hyperlipidemic groups. In addition, there was a significant
increasing action for all detoxifying enzymes in both diabetic and
hyperlipidemic groups. Conclusion: the present study concluded that
F. vesiculosuss had beneficial effect as hypoglycemic, hypolipidemic and
immunomodulatory in all studied groups. As well as, it lowered body
weight and improve liver function in hyperlipidemic rats.