الفهرس 
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Abstract
Hepatitis C virus (HCV) is a major health problem in Egypt with the risk of liver fibrosis, cirrhosis and hepatocellular carcinoma (HCC) development. Assessment of hepatic fibrosis and its changes after therapy is important to evaluate the possibility of fibrosis regression or progression with many complications as HCC development. Liver biopsy (LB) is the gold standard method for assessment of hepatic fibrosis. FibroScan, FIB- 4 and APRI are non-invasive methods used in assessment of hepatic fibrosis. To study the changes of liver fibrosis that occur after treatment ; liver biopsy is the most accurate method but it is invasive method with many complications, contraindications, expenses and it is not accepted by most patients. FibroScan can be used as a method regarding hepatic fibrosis assessment with accepted AUC. APRI and FIB-4 have lower AUC and can be used as a help complementary tools.