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Abstract This study included 50 neonates aged 7 days or more delivered in Minia university children’s hospital or referred from outside. They were subjected to thorough history taking, clinical examination and the following investigations ; 1-CBC 2-CRP 3-Blood culture and sensitivity -Our results showed that among the studied neonates 33(66%) were preterm and 17(34%) were full term. 40(80%) of the studied neonates were delivered in the hospital while10 (20%) were delivered outside. -The bacterial growth was significantly more frequent among neonates delivered in the hospital than those delivered outside the hospital (P-value <0.05). - Our study showed that the hospital-acquired neonatal sepsis and CANS in developing countries showed a predominance of Gram-positive organisms with staphylococcus species, suggesting potential similarities in major pathogens between CANS and hospital acquired neonatal sepsis in developing countries. There is no significant difference between the antibiotic sensitivity pattern of the bacterial isolates of hospital and community acquired neonatal sepsis as P-value > 0.05. -Vancomycin is the most sensitive antibiotic to the most isolated bacteria in community and hospital acquired sepsis and the most effective antibiotic against gram +ve organisms followed by amikacin and imipenem whereas the sensitivity of gram –ve organisms to the antibiotics is less clear due to small number of studied cases. |