الفهرس 
Biological applicationOnly 14 pages are availabe for public view
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Abstract
The master thesis include four main chapter
I- Introduction
This chapter includes an overview of previous researches for
complexes of hydrazone ligands and their applications
II- Aim of the work
The work aimed to prepare and characterize new Schiff base
ligand and its metal complexes aiming to study their effects
in the treatment of tumor .
III- Experimental
This chapter contains the chemical and instruments used in
Practical part of thesis as follow:
1) Preparation of the Schiff base ligand and its metal complexes.
2) characterization of the ligand and its complexes using:
Physical techniques such as molar conductance and magnetic
susceptibility
Elemental analyses (C, H, N, Cl and M).
Spectral techniques as IR, UV- Vis., 1HNMR, mass spectra
and ESR measurements.
Thermal techniques as DTA. and TGA
3) Measurement of biological activity
English summary
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iv. Results and discussion
This chapter includes Spectroscopic (IR,1H-NMR, UV-VIS, Mass and
ESR spectra) and elemental studies of the (N’1,N’4)-2,3-dihydroxy-
N’1,N’4-bis((2-hydroxynaphthalen-1-yl)methylene)succinohydrazide
(H6L) and its metal complexes were reported. The magnetic properties
and thermal analyses (DTA and TGA) were also carried out. The IR
spectra of the prepared complexes suggested that, the ligand adopted
either a bidentate or a tetradentate fashion, bonding to the metal ion
through the azomethine nitrogens and the two phenolic oxygen atoms
(ONNO). Electronic spectra and magnetic su Zinc(II) complexes (14) and
(15), cadmium(II) complexes (16-18) and lead(II) complex (19) show
diamagnetic property.
sceptibility measurements revealed its geometry for all complexes
The analytical and physicochemical data confirmed the composition and
structure of the newly obtained compounds. The ESR spectra of solid
Cu(II) complexes (2-5) show axial type indicating a d(X2-y2) or d(Z2)
ground state with significant covalent bond character. The ligand
behaved as monobasic or neutral bidentate. The complexes adopted
distorted octahedral geometry around the metal ion. The ligand recorded
weak cytotoxic activity in the time that some complexes were very
prospective compared to ALMURAN (zathiopeine) standard drug. This
indicates enhancing of antitumor activity upon the coordination process.
Cu(II) complex (12) showed the highest cytotoxic activity against MCF-7
with IC50 5.12μg/ml. This finding indicated to a very promising
candidate as anti-breast carcinoma meanwhile, Cd(II) complex (18)
recorded the highest activity against Hep-G2 (human liver cancer) with
IC50 3.7 μg/ml.