الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Osteoarthritis (OA) is a common degenerative disorder of the articular cartilage associated with hypertrophic bone changes resulting in impaired movement, inflammation, pain and ultimately disability. Although it can affect any synovial joint, OA in knee joints has the highest prevalence and greatest association with disability. Alternative or complementary nutrients such as glucosamine and chondroitin as well as some other herbal products have been used worldwide either for the treatment of OA, or at least to potentially help in reducing symptoms.
At this study we examine the potential of quercetin (QUE), a naturally occurring flavonoid, in management of knee OA rat model, in comparison to standard non-steroidal anti-inflammatory drugs (indomethacin, INDO). Through the changes in protein expression of transforming growth factor-beta (TGF-B) by western blotting, expression of mRNA of both cartilage oligomeric matrix protein (COMP) and tissue inhibitors of matrix metalloproteinase1 (TIMP1) by RT-PCR, hyaluronic acid (HA) concentration by capillary electrophoresis and evaluation of reactive oxygen metabolites by colorimetric method coinciding with histopathological and radiological findings.