الفهرس 
Introduction
Early human embryonic developmentOnly 14 pages are availabe for public view
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Abstract
Recurrent pregnancy loss (RPL) is the most common complication of pregnancy, affecting approximately 15% of all clinically recognized pregnancies in the general population.
This study was conducted to gain further information about the possible genetic causes of RM in our patients.
In our study we investigate the expression of p-AKT and p-ERK protein in human placenta.
The data of Western blot presented here demonstrtated that protein levels of p-ERK and p-AKT in RM were significantly lower than those in their adjacent normal womens nearly 6.06 folds and 3.78 fold respectively(P<0.001). Our study suggests that p-ERK and p-AKT are signicantly decreased during RM.
Which demonstrates that the activation of ERK pathway may and AKT pathway plays a significant role in RM.The data suggest that decrease expression of ERK and active ERK also AKT and active AKT occurs less frequently during RM may play a role in this process.
This suggests that p-ERK and p-AKT may be markers of RM. Recent findings from our group indicate that MAPK/ERK1/2 pathway is involved in trophoblast proliferation and migration.
The present study indicates that ERK and AKT play an important role in the implantation and placentation, high level and mature state of both is beneficial to the maintenance of normal pregnancy.
Recommendation
In this study conclusion revealed that further research should be carried out to investigate the downstream molecular interaction.
ERK1/2 and AKT, all of which contribute to the pathological hyperphosphorylation, should be investigated as potential therapeutic drugs for RM.
Further research for genetic causes should be done to as from this study revealed positive correlation between RM and genetic causes.