الفهرس 
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Abstract
A number of new 2–methylbenzimidazole derivatives were
synthesized and structural elucidation of the compounds was performed by
IR,1H-NMR and Mass spectroscopic data . Studies and researches have
shown, that derivatives of 2–methylbenzimidazole and its own nucleosides
have biological activity against gram-negative and gram-positive bacteria,
which infect humans and animals and its medical uses became act as a
remedy against these types of bacteria. Sugar hydrazones, N-substituted
acyclic nucleoside analogues and arylidene derivatives bearing imidazole
were prepared showed mild to high activity against the tested organisms
(staphylococcus aureus, micrococcus, salmonella typhi, salmonella para
typhi, Escherichia coli, aspergillus flavus, aspergillus fumigates,
aspergillus ochraceus and candida albicans),they showed antibacterial and
antifungal activities. Synthesis of new compounds of these families with
the effectiveness of high biological and fewer side effects take our
attention.
The starting compound 2–Methylbenzimidazole (171) was prepared
from o-Phenylenediamine (170), Acetic acid and in presence of water
under reflux. The compound 171 was allowed to react with
ethylchloroacetate in dry acetone and in the presence of anhydrous
potassium carbonate to afford 1-ethoxycarbonylmethyl-2-
methylbenzimidazole (172). Treatment of 172 with hydrazine hydrate in
ethanol under reflux gave the corresponding hydrazide 173 in 83 %
yields (scheme 3).