الفهرس | Only 14 pages are availabe for public view |
Abstract Psoriasis is a chronic relapsing inflammatory skin disease mostly characterized by red, scaly, sharply demarcated, indurated plaques. Commonly affecting the scalp, trunk, elbows, knees and genital areas but can affect any part of the body including nails. Psoriasis is a genetically determined disease mainly driven by abnormal differentiation secondary to activation of T- cells or antigen presenting cells, which in turn release various chemokines and cytokines that signal keratinocytes to hyperproliferate. Interleukin-6 (IL-6) is one of the most important inflammatory cytokines. It is a component of normal human skin and it has been immunologically detected in basal keratinocytes, endothelial cells, mononuclear cells and fibroblasts. IL-6 plays a central role in a variety of host defense mechanisms, such as the immune response, hematopoiesis and acute-phase reactions. Phototherapy such as NB-UVB therapy has become one of the most commonly used modality for the treatment of a variety of skin diseases including psoriasis. The aim of this work was to evaluate the role of IL-6 in the pathogenesis of psoriasis, to determine the effect of NB-UVB therapy on serum IL-6 level in patients with psoriasis and to determine the relationship between serum IL-6 levels and disease activity after such treatment. Sixty subjects; 30 patients with psoriasis and 30 age and sex matched healthy controls were included. Each patient was subjected to a detailed history taking and examination. Blood samples were taken from all subjects to assess serum level of IL-6 by ELISA Summary 131 technique before and after treatment. NB-UVB treatment sessions were given for the patient group three times per week for 3 months. Serum IL-6 levels and PASI scores were measured at the beginning of the study and after 3months of treatment. In the present study serum IL-6 levels in the patient group were significantly greater than those of controls, in addition; serum IL-6 levels decreased markedly in a statistically significant manner after NB-UVB therapy in patients with psoriasis in comparison to pretreatment levels. Patients with psoriasis have elevated levels of pretreatment and post treatment serum IL-6 in comparison to controls with significant reduction of mean serum IL-6 level and PASI scores after NB-UVB. There was a highly significant correlation between serum IL-6 level and PASI scores among patients with psoriasis before and after treatment. There was significant correlation between serum IL-6 level and duration of disease in patients with psoriasis. |