الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
In conclusion, the results of our study, on a large series of patients with pancreatic and biliary cancer suggest the importance of few parameters, performance status, tumor markers (CA19.9, CEA), type of surgery(when performed), histological type, grading, stage, site of the disease, Lymph node status, margin status, perineural invasion and treatment modality received (chemotherapy, radiotherapy, surgery and supportive care).
We analysed the prognostic impact of each variable on different survival parameters, in the present study, all factors under investigations were significantly related to survival time, we distinguished factors that influence survival time, these factors were divided in to three groups, the first include the patient clinical characteristics, the second group include the tumour characteristics and the final group of factors were related to therapeutic modalities.
The role of theses parameters (which are commonly available) may be relevant in the clinical practice in order to identify subgroups of patients with unfavourable or favourable prognosis before the first line chemotherapy treatment and then to guide treatment choices.
This information is needed for the development of effective multidisciplinary treatment strategies and the design of future clinical trials.
Prognosis of pancreatic and biliary cancer is still poor now days and despite the interesting advance provided by combinations, survival results remain disappointing, further research focused on new combinations, incorporating the new targeted therapies and identifying potential predictive factors of response, also confirming the ones analysed in the present study, are required to be able to offer effective tailored therapies to our patients.