الفهرس 
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Abstract
This study was performed to assess the anti-nuclear antibodies before and after laparoscopic drilling.
Eighty women with polycystic ovary syndrome were selected for this work from those attending the infertility clinic at Ain Shams University Hospital.
The diagnosis of polycystic ovary syndrome was based on clinical, sonographic and endocrinological documentation.
Those who had fulfilled the primary inclusion criteria (n=80) were scheduled for laparoscopic ovarian drilling and all those women were be sampled by blood samples before and one month after laparoscopic ovarian drilling to assess the anti-nuclear antibodies.
Data were analyzed using IBM© SPSS© Statistics version 22 (IBM© Corp., Armonk, NY, USA) and MedCalc© version 14 (MedCalc© Software bvba, Ostend, Belgium).Normality of numerical data distribution was examined using the D’Agostino-Pearson test. Normally distributed numerical variables were presented as mean ± standard deviation and skewed numerical variables as median (interquartile range). Categorical variables were presented as number (%) .The Wilcoxon rank signed ranks test was used for comparison of paired numerical variables. For comparison of paired categorical variables, the McNemar test was used.Correlations among numerical variables were tested non-parametrically using the Spearman rank correlation.A two-sided p-value <0.05 was considered statistically significant.
Anti-nuclear Antibodies assessment show increase in serum ANA before and after laparoscopic drilling and this difference was found to be statistically significant.
The findings of the present study collectively not only revealed a high ANA production in some patients with PCOS, but also suggested that laparoscopic ovarian electrocauterization might have exposed ovarian antigens to the immune system and consequently stimulated autoimmune reactions in the patients.