الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
This study included 50 subjects divided into three groups:
Group I (Idiopathic Thrombocytopenia Purpura group): Included 25 ITP patient with severe thrombocytopenia.
Group II (Chronic Hepatitis C patients group): Included 25 chronic Hepatitis with severe thrombocytopenia.
Group III (Control group): Included 10 healthy subjects (as control group).
All patients and control were submitted to the following investigations:
Laboratory investigations:
Complete Blood Count (CBC).
Liver Function Tests ( ALT , AST , Albumin and INR )
Renal Function Tests (Blood urea , Serum Creatinine )
HCV and HBV Antibody detection by ELISA
Special investigations:
Bone Marrow Biopsy and examinations to group 1 and group 2
Immature Platelet Functions % for all patients and control group.
Results of different groups were compared with each other and were summarized as follows:
There was statically significant difference in ALT, AST, Albumin and INR when group 2 was compared to group 3. This significant difference was noticed only in ALT and AST when group 1 was compared to group 3.
There was significant decrease in platelet count in group 1 as compared to group 2 and group 3.
There is significant increase in IPF in group 1 compared to group 2 and group 3
In patients with chronic Hepatitis C patients were further subdivided into 2 subgroups:
Group Ia: chronic hepatitis C with splenomegaly
Group Ib: chronic hepatitis C without splenomegaly
And we found that there is insignificant difference in platelet count and IPF between the 2 subgroups.
There was a statistically significant negative correlation between platelet count and IPF in group 1 ( p =0.04 ) and group 2 ( p value = 0.001 ).
There was a significant negative correlation of platelets count with AST and ALT ( p. value = 0.001 )
And there was a significant positive correlation between platelets count and serum albumin ( p value =0.0001 )
And there was a significant positive correlation of IPF% with AST and ALT (p value = 0.002) and negative correlation with albumin ( p value =0.04)
In group 1a there was statistically significant positive correlation of platelets count with Haemoglobin ( p value =0.001) and RBCs count (p value=0.02 ).