الفهرس 
Introduction and Aim of the Work
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Hepatocellular carcinoma, the main primary malignant tumor of the liver, is one of the leading causes of cancer-related deaths worldwide. The treatment with conventional chemotherapeutic agents is usually of limited benefit due to their unlimited chronic and acute systemic toxicities that leads almost to several serious side effects. Historically, the plants have a long history of use in the treatment of cancer. In this regard, BER, represents a new insight as a promising candidate of these natural compounds. Accumulative evidences, in both in vitro and in vivo studies, have demonstrated that BER posses anticancer potential in some carcinomas with little resistance and low toxicity to normal tissues. More recently, the several in vitro and in vivo studies explored BER as a chemosensitizing phytochemical in combination with approved chemotherapeutic agents as an alternative approach for cancer control and treatment. In light of above knowledge, the current study aimed to evaluate the antitumor efficacy of BER in combination with DOX on a chemically induced HCC in rat model.
In the current study, DOX and BER were investigated individually and in combination to withstand against DENA-induced HCC in rats which was induced by received DENA in their drinking water (100mg/L) for 8 weeks. Intravenous administration of DOX 2.5 mg/kg (i.v., weekly) via tail vein and oral administration of BER (100 mg/kg) for 4 weeks alone as well as a blend of them in the same doses were started after one month of the end of DENA administration. One week after the last treatment blood samples and liver were collected and the animals were sacrificed.