الفهرس 
Vitamin DOnly 14 pages are availabe for public view
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Abstract
Colo-rectal cancer is one of the major causes of cancer deaths world-wide. Multiple factors are responsible for the etiology of this cancer since the colorectal mucosa is directly influenced by nutrients reaching the colonic lumen and mucosal cells.
Lifestyle and diet can contribute to progression of early malignant colonic lesions by modulating growth factors thatinteract with inflammatory pathways. The propensity of Vitamin D to prevent CRC was supposed for more than a quarter of a century.
One of the first clues indicating this link was the finding of an inverse relationship between mean solar radiation and age adjusted CRC death rates.Since that time, a number of studies have suggested a link between vitaminD level and the incidence of human CRCformation. An association between vitamin D status andreduced risk of CRC has been found in ethnically diverse populations.
The aim of this study is to To study the relationship between Vitamin D level and the risk of colorectal cancer.
Our study was conducted on 40 person, 20 patients newly diagnosed colorectal cancer before surgical intervention and the other 20 were healty adult pesrons
Cases were selected from general surgery wards& outpatient clinics at Ain Shams University Hospital, before surgical intervention or receiving oncological treatment.
All participants were subjected to full medical history taking, General clinical examination and Laboratory investigations including (Hb, S.creatinine, total, ionized Ca, phosphorus, Mg++, alkaline phosphates and 25 hydroxy vitamin D level) plus imaging and colonoscopy for the patients with colo-rectal cancer.
Patients with chronic systemic diseases such as renal, liver cell faliure were excluded from our study.
We classified our subjects into patients and control:
Group 1: patients, newly diagnosed with colo-rectal cancer
Group 2: control (healthy subjects)
On comparing GroupΙ (Colorectal cancer diseased patients) with GroupΙΙ (control), we found that, there was highly significant difference between both groups in Serum25 hydroxychlolelcalciferol (p-value 0.002)being lower in the cases.
There was also significant difference between the cases and control regarding Hemoglobin (p-value <0.001) being lower in cases (table 10), and in Alkaline Phosphatase (p-value<0.001), Ast (p-value =0.017), Alt (p-value=0.002) being higher in the cases
There was no significant difference in total Ca (p-value =0.915), PO4 (p-value= 0.333) Mg (p-value =0.194) and Creatinine(p-value=0.406).
ROC curve done to assess the predictive accuracy of vitamin D as risk factor for colo-rectal cancer, results show that Vitamin D Value with cut off value <=9 ng/ml has sensitivity85% and specificity 70% with predictive accuracy 80%
In conclusion, our results revealed that serum vitamin D is lower in colo-rectal carcinoma cases compared to normal persons, a result which may suggest a role for vitamin D in prevention for colo-rectal cancer.