الفهرس 
REVIEW OF LITERATUREOnly 14 pages are availabe for public view
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Abstract
In light of the dramatic increase in the prevalence of nonalcoholic fatty liver disease (NAFLD), noninvasive, simple, reproducible, and reliable biomarkers that can allow identifying patients with nonalcoholic steatohepatitis (NASH) among NAFLD patients are greatly needed.
The aim of this study was :
To highlight the role of some noninvasive Biomarkers as: biomarkers of fibrosis (FibroTest, Fibronectin), biomarkers of inflammation (HsCRP, TNF-α), biomarkers of oxidative stress and cytoprotective enzymes (NO, MDA, SOD, GSH-Px) in diagnosis of non alcoholic steatohepatitis (NASH), aiming to reduce the use of liver biopsy.
This study included 4 groups (90 subjects): group I (18 patients) with simple liver steatosis, group II (26 patients) with mild NASH, group III (16 patients) with Severe NASH, and group IV (30 healthy subjects).
The most important findings of the present study were :
The mean serum levels of MDA, NO, HsCRP, TNF-α, Fibronectin and also Fibro test values were significantly increased in patients with Severe and Mild NASH when they compared with simple liver steatosis group and healthy control group, while serum GSH-Px, and SOD levels were significantly decreased in patients with Severe and Mild NASH when they compared with simple liver steatosis group and healthy control group.
from the results of the present study :
-We can diagnosed NASH with no more ask for invasive liver biopsy by many non-invasive biomarkers.
-Insulin resistance reflected by an elevated blood sugar and abnormal lipid profile was a corner stone in the laboratory diagnosis of the common clinical forms of NAFLD and NASH.
-We recommended the use of FibroTest as a first-line assessment tool for liver fibrosis