الفهرس 
CHRONIIC VENOUS IINSUFFIICIIENCYOnly 14 pages are availabe for public view
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Abstract
Platelet-rich plasma (PRP) is a volume of autologous plasma that has a platelet concentration above baseline.
The use of Platelet-Rich Plasma (PRP) in medicine has become increasingly more widespread during the last decade. The use of PRP in medicine is based on the fact that platelets contain many growth factors in their alpha granules. These factors have a well-known role in the process of tissue repair. Venous ulcers are the most common form of leg ulcers which has a significant impact on quality of life and work productivity. Conventional therapies are not able to provide necessary growth factors that can modulate healing processes. chronic non healing ulcers lack the necessary growth factors (GFs) and hence do not heal well.
The present study was conducted to compare the clinical efficacy of platelet rich plasma in the management of chronic venous ulcers (as regard the time of complete ulcer healing or shrinkage in size) with the conventional methods of treatment of venous ulcers (compression + dressing).
To achieve this aim this study was conducted on 40 patients with chronic lower limb venous ulcer, they were divided into 2 equal groups with no statistically significant as regard personal and medical data, etiology of ulcer and as regard length, width and size of the ulcer before the start of treatment.
Group A (cases): included 20 patients with chronic venous ulcer who were treated with platelet rich plasma -topically applied to the ulcer then dressed by vasline gauze and compressed by graduated elastic stocking- for 6 sessions with one week interval between sessions.
Group B (control): included 20 patients with chronic venous ulcer who were managed conservatively by compression using graduated elastic stockings below the knee and dressing using saline and vasline guaze weekly for 6 weeks.
Results of the study showed marked improvement in patients treated with PRP when compared to patients treated conservatively who showed mild improvement after 6 weeks on conventional treatment, with statistically significant difference between cases and controls groups as regard length, width and size of the ulcers at the end of treatment after 6 weeks, adding more evidence to treatment efficacy with PRP when compared with the traditional methods.
Results also showed that the percentage of complete ulcer healing in cases group was much higher with highly statistically significant difference when compared to control group.
There were no side effects and there was a decrease in pain associated with the ulcers. Results of this work showed that DM, was an independent factor affecting mean change in size of the ulcer and impairing healing.