الفهرس 
Epiepsy diseaseOnly 14 pages are availabe for public view
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Abstract
Epilepsy is a disorder of the brain characterized by an enduring
predisposition to generate epileptic seizures and by neurobiological, psychological
and social consequences of this condition. The definition of epilepsy requires the
occurrence of at least one epileptic seizure. Worldwide there are an estimated at
least 65 million people living with epilepsy.
Pentylenetetrazol (PTZ) is an acknowledged model for epilepsy and refers to
a phenomenon in which repeated injection of a convulsant causes gradual seizure
development culminating in generalized tonic–clonic seizures associated with a
cognitive deficit. Use of seizure models involving administration of
pentylenetetrazol (PTZ) are integral components in the process used to identify
clinically useful anticonvulsant drugs.
The psychological and physiological benefits of Ginkgo biloba are said to be
based on its primary action of regulating neurotransmitters and exerting
neuroprotective effects in the brain, protecting against or retarding nerve cell
degeneration. The anti-oxidative and antiperoxidative properties of its flavonoid
component and the anti-inflammatory activity of its terpenoid component are
thought to be the basis for the purported efficacy of GB in Alzheimer’s disease
(AD). Other studies indicated that GbE-761 may have anticonvulsant activity.
L-carnitine, among a wide array of target neuroprotective agents, is of
particular interest in neurons due to its role in amino acid synthesis, ATP
metabolism, mitochondrial fatty acid transport, as well as its antioxidant effects.