الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The MSC population plays a major role in the skeleton and extra skeletal sites in tissue repair including stromal proliferation and site specific stromal cell differentiation. Furthermore, the MSC population plays a major role in tissue immune reactions and immunosurveillance. It was found that TNFα levels in peritoneal fluid in patient of endometriosis were significantly higher compared to controls with positive correlation has been found between TNFα and IFNγ levels, suggesting their synergistic stimulatory effect on the peritoneal fluid cells. But unfortunately, a trial involving 21 participants was included of the effect of anti-TNF- drugs in treatment of pain associated-endometriosis. The results showed no evidence of an effect of infliximab, one of the known anti-TNF- drugs, on pelvic pain, indicating a missing link between the peritoneal inflammatory milieu and endometriosis. Recently IL-22 has emerged as a key cytokine that both regulates inflammation and also stem cell function in other niches. It was found that interleukin-23 levels were significantly higher in peritoneal fluid of infertile women with minimal/mild endometriosis, and this may be implicated in the subfertility of these patients. Interestingly, the expression of IL-22 and its receptors was found to be increased in the eutopic endometrium and ectopic lesion from women with endometriosis. There is no data thus far on the effect of IL22 on MSC function. Given that MSCs are best defined and characterised in the skeleton this work explored IL-22 effects on “gold standard” bone marrow MSCs. from this work, IL-22 receptor could be detected on MSCs intracellularly and up-regulation of IL-22 receptor in primed MSCS with different cytokines was found. IL-22 could enhance MSCs proliferation and migration significantly after their priming compared to non-stimulated MSCs. IL-22 increased MSCs differentiation while IFNγ and TNFα (with or without IL-22) strikingly suppressed it from this data, we can build the theory of the role of endometrial MSCs in formation of endometriosis after their immunomodulation by the peritoneal inflammatory milieu, with a corner stone role of IL-22, encouraging the performance of further investigations about the potential role of usage of biologics as anti-IL-23 pathway drugs in treatment of endometriosis.