الفهرس 
Intracanal medicationsOnly 14 pages are availabe for public view
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Abstract
The aim of the study was to compare the cytotoxicity and the flow
properties of Triple antibiotic paste versus propolis as an intracanal
medicament.
Pastes of Triple Antibiotic pastes were prepared and and sterilised
by ethylene oxide gas and soaked in E-MEM for 7 days .Samples
were placed in a dark container at 37 °C and 100%.
Cytotoxicity was evaluated using the MTT assay at 24 , 48 and 72
hours, IC50 values were calculated as well as the therapeutic dose
cytotoxicity values. Flow properties were evaluated by putting the
pastes between two parallel glass slabs and inserting a weight of
500grams on the parallel slabs , diameter of the circles formed were
measured and calculated using a vernier ruler. Data was calculated
and statistically analysed.
MTT results showed statistically insignificant difference
between Triple antibiotic paste when evaluated at 11 different
doses .When IC50 values were calculated from readings obtained
from MTT assay results showed statistical significant differences
with the lowest IC50 value recorded was for Propolis at 48 hours.
When cytotoxic action of therapeutic values was tested from MTT
assay readings , results showed significant statistical differences (P
value : 0.0008) between both propolis and Triple Antibiotic Paste with highest viable cell percentage to triple antibiotic paste with
87.53% vitality at 48 hours followed by 76.63% vitality at 72 hours
of TAP followed by 76.32 vitality of TAP at 24 hours then Propolis
with a low cell vitality of 34.21% at 72 hours then 32.54% vitality at
48 hours and the lowest cell vitality percentage was found for
Propolis at 24 hours 20.5% suggesting it to have the most cytotoxic
action.
Flow rate results showed insignificant statistical difference between
flow of Triple antibiotic paste and Propolis paste.