الفهرس 
Salivary gland cancer
Types of cancers that can affect salivary glandsOnly 14 pages are availabe for public view
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Abstract
Neoplasms of the salivary glands account for 2% to 7% of head
and neck neoplasms but less than 1% (approximately 0.3%) of
malignancies from all body sites. The most frequent malignant salivary
gland tumors are the mucoepidermoid carcinoma, adenocystic
carcinoma and adenocarcinoma. Because of their rarity, the number of
histologic subtypes, and the morphologic overlap and heterogeneity
among these subtypes, salivary gland tumors often remain
diagnostically challenging even for experienced pathologists.
Adding to the diagnostic difficulty, is the fact that new tumors
and improvements in understanding the biologic behavior of previously
established subtypes are continually being recognized.
This study was conducted to immunohistochemically
investigate the expression of Nm23 and GLUT1 in malignant salivary
gland tumors.
The material of this study consisted of twenty five formalin
fixed, paraffin embedded specimens of malignant salivary gland
tumors, and they were diagnosed as eleven cases of adenocystic
carcinoma, eight cases of mucoepidermoid carcinoma, three cases of
acinic cell carcinoma and one case from each of epithelial
myoepithelial carcinoma, recurrent malignant myoepithelioma and
carcinoma ex. pleomorphic adenoma.
Also one case of normal salivary gland was used as control
case.
Histopathological examination, using hematoxylin and eosin,
was used to confirm the diagnosis. The immunostained slides were
examined by light microscope and photographed. Analysis and interpretation of the results were performed using
the image analysis software (Image J.1.41a, NIH, USA) to measure the
total mean surface area of immunopositivity for Nm23 and GLUT1.
Statistical analysis was performed using ANOVA and Tukey
pair wise test for multiple comparisons of mean.
Immunohistochemical results of the present study revealed that
a lower expression of Nm23 in malignant salivary gland compared to
its expression in normal control, while a higher expression of GLUT1
in malignant salivary gland compared to its expression in normal
control.
Clinicopathological findings showed an over expression of
Nm23 in low grade mucoepidermoid carcinoma and primary malignant
salivary gland tumors, while over expression of GLUT1 was in high
grade mucoepidermoid carcinoma and recurrent malignant salivary
gland tumor.
Based upon these data it could be concluded that expression of
Nm23 and GLUT1 in malignant salivary gland tumors might indicate
the usefulness of these markers in detection of biological behavior of
malignant salivary gland tumors.
Statistical results revealed that there was a statistically
significant difference in mean area fraction of Nm23 immunopositivity
when comparing normal control to adenocystic carcinoma, low and
high grade mucoepidermoid carcinoma, acinic cell carcinoma,
epithelial myoepithelial carcinoma and recurrent malignant
myoepithelioma. Also there was a statistically significant difference
between adenocystic carcinoma and recurrent malignant
myoepithelioma, and a statistically significant difference between acinic cell carcinoma with each of epithelial myoepithelial carcinoma
and recurrent malignant myoepithelioma.
While in GLUT1 there was a statistically significant difference
in mean area fraction between normal salivary gland and recurrent
malignant myoepithelioma.
Based upon these data we could conclude that there is a reverse
relationship between Nm23 and malignancy. But in contrary, there is a
direct relationship between GLUT1 and malignancy. So the expression
of Nm23 and GLUT1 in malignant salivary gland neoplasms might be
useful in detection of biological behavior and prognosis of malignant
salivary gland tumors.