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Abstract Paravertebral block is a technique of regional anesthesia in which local anesthetic is deposited adjacent to where spinal nerves emerge from the intervertebral foramina resulting in an ipsilateral somatic and sympathetic nerve blockade of the respective dermatomes. Dexmedetomidine is a new drug which has sedative and analgesic effects, so it can be used to relief mastectomy pain through addition to local anesthetics in paravertebral block. In this study we aimed to make a comparison between fentanyl and dexmedetmedine as adjuvants to bupivacaine in thoracic paravetebral analgesia in patients undergoing unilateral breast surgery under general anesthesia. This prospective randomized controlled study was carried out in Tanta university hospitals after approval from ethical committee and informed written consent describing benefits and hazards of technique. The study included sixty patients, aged 18–60 years, ASA physical status I-II scheduled for elective modified radical mastectomy for treatment of unilateral breast cancer under general anesthesia. |