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Abstract Chronic renal failure (CRF) is a global health problem; its incidence appears to be increasing. Egypt has the 2nd highest prevalence of CRF among the Middle East countries. CRF requires lifelong dialysis or renal transplantation. There is an obvious need for alternative approaches that would reduce the cost of dialysis, drug therapy and renal transplantations. One such approach is the use of Gum Arabic (GA). GA is defined as dried gummy exudates of mature trees of Acacia Senegal. It is supposed to have anti-inflammatory and/or anti-oxidant effect. The main objective in our study was to study the role of Gum Arabic in an adenine model of CRF. Material & Methods Sixty young adult male albino rats were used in this study and were divided into the following groups: Group I (Control Group): consisted of ten rats; they were used as control for all groups. Group II (Gum Arabic Group): consisted of twenty rats; they were subdivided into subgroup II (a) & II (b). Each received Gum Arabic (12 gm. dissolved in 100 ml of drinking water). They were sacrificed after 4 & 6 weeks respectively. Group III (CRF induced Group): consisted of ten rats, received a daily adenine dose (0.075 grams was added to 10 grams of food for each rat). They were sacrificed after 4 weeks. |