الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Premature ovarian failure (POF) is defined as hypoestrogenic hypergonadotropic secondary amenorrhea that occurs in women under the age of 40 years. It is characterized by loss of oocytes, lack of folliculogenesis and ovarian estrogen production, and infertility. Stem cells can be defined by their capacity to self renew as well as to differentiate into one or more mature cell types. Mesenchymal stem cells (MSCs) represent a promising tool for new clinical concepts in supporting cellular therapy. Bone marrow (BM) was the first source reported to contain MSCs. However, for clinical use, BM may be detrimental due to the highly invasive donation procedure and the decline in MSC number and differentiation potential with increasing age. Many investigators have reported that mesenchymal stem cell (MSC) transplantation can ameliorate the structure and function of injured tissues.
The aim of this study was to evaluate therapeutic Potency of mesenchymal stem cell transplantation in mice with chemotherapy induced ovarian, a step towards invention novel treatment in premature ovarian failure.
This study included sixty mature female mice that weighed between 22- and 25 gm. Mice were fed with chow and water ad libitum under controlled temperature (28oC-30oC). To ensure adequate adaptation, mice were observed in this environment for 14 days prior to commencing treatment through which animals were weighed weekly.