الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Hepatocellular carcinoma (HCC) represents an international public health concern as one of the most common and deadly cancers worldwide. It is the third most common cause of cancer-related death worldwide. In Egypt, HCC is the second most common cancer in men and the 6th most common cancers in women.
HCC is atypical malignancy that slowly unfolds on background of chronic inflammation mainly due to exposure to hepatitis viral infection and cirrhosis. The worldwide heterogeneous incidence reflects variations in the main risk factors which include cirrhosis, viral hepatitis (HBV and HCV), aflatoxin, exposure to pesticide and genetic host factors.
Genetic host factors play an important role in HCC development. The most common form of genetic variation between individuals is SNP which correspond to a modification of a DNA sequence due to the change of a single nucleotide.
This study aimed to study the association of IL-17A gene polymorphism and hepatocellular carcinoma, The study was conducted on 95 subjects divided into 4 groups, Group A: 20 healthy controls, Group B: 20 chronic hepatitis C with fibrosis, Group C: 20 chronic hepatitis C with cirrhosis, and Group D: 35 hepatocellular carcinoma patients.
All individuals were subjected to full clinical examination.