الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
UC is characterized by recurring episodes of inflammation limited to the mucosal layer of the colon. It commonly involves the rectum and may extend in a proximal and continuous fashion to involve other parts of the colon.
The aim of the present work was to study the diagnostic role of platelet indices in patients with UC and its correlation with disease activity.
The present study was conducted on 50 patients with lower gastrointestinal symptoms indicated for colonoscopy selected from the endoscopy unit and the outpatient clinic of Tropical Medicine Department in Menoufia University hospital in the period from July 2013 to June 2014. They were 24 males (48%) and 26 females (52%), their ages ranged from 23 to 62 years. In addition to 20 healthy persons of matched age and sex were selected as control group. Patient and control were classified into the following groups: GI included 30 naive patients with clinical, laboratory, colonoscopic and histopathological findings of UC. GII included 20 patients with lower gastrointestinal symptoms but without clinical, laboratory, colonoscopic and histopathological findings of UC or any other organic colonic disease and they were diagnosed as IBS according to Rom III criteria. GIII included 20 healthy persons as control group.
Patients and controls were subjected to the following: Full history taking, full clinical examination, laboratory investigations including: Complete stool and urine analysis, ESR and CRP titre, complete blood count, colonoscopy and biopsy taking.
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histopathological examination of biopsy specimens and platelet indices.
Statistical analysis of the present study revealed that:
There was no significant o significant o significant o significant o significant o significant o significant o significant o significant o significant o significant o significant difference between studied groups as regard age and sex distribution.
Some of clinical manifestations were present in both groups [difficult clinical differentiation]. Rectal bleeding absent in all GII patients.
There was highly significant increase in the mean values of ESR & CRP in GI patients in comparison with GII &GIII. Significant decrease in the mean values of Hb concentration in GI patients in comparison with GII &GIII and in GII when compared with GIII. Significant increase in the mean values of platelet count in GI when compared with GII & GIII. No significant difference between GII &GIII as regard ESR, CRP, WBC& platelet count.
Colonoscopic examination revealed the presence of inflammation of different severity & extent in all GI patients while there was mild inflammation in 5 patients in GII.
There were presence of architectural changes &chronic inflammatory infiltrations (diagnostic of UC) were present in all of GI patients & were associated with other histopathological findings of activity in various proportions.
Histopathological study of IBS group suggests low grade chronic inflammation with T-lymphocytes, none of histopathological findings characteristic for diagnosis of UC present in IBS group.
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There were highly significant decrease in the mean values of MPV &PDW and highly significant increase in the mean values of PCT% in GI patients in comparison to GII & GIII. While there is no significance difference between GII& GIII as regard platelet indices.
Platelet indices at related cut off points were valuable in evaluating activity of UC (UCAI) with various accuracy, sensitivity and specificity.
There was significant negative correlation between MPV& PDW and UCAI (Mayo score).
There was significant positive correlation between PCT&UCAI (Mayo score).
There was significant positive correlation between PCT&UCAI (Mayo score).
There was significant negative correlation between MPV and ESR& CRP.
There was significant negative correlation between PDW and ESR& CRP.
There was positive correlation between PCT% and ESR (significant) & CRP (highly significant).