الفهرس 
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Abstract
Gemifloxacin (GMFX) reacts with Y(III), Zr(IV), La(III), Ce(IV)
and U(VI) at room temperature, also, reacts with Zn(II), Zr(IV), Pd(II), Ce(IV), Th(IV) and U(VI) in presence of 2,2’-bipyridine (Bipy) and reacts with Zn(II), Zr(IV), La(III), Ce(IV), Th(IV) and U(VI) in presence of 1,10-phenanthroline monohydrate (Phen) in ethanol and acetone as a solvents to form solid complexes. The complexes were obtained as colored powdered materials and characterized using elemental analysis, magnetic measurements, melting point, molar conductance, infrared, electronic, 1H NMR, mass spectra and thermogravimetric analyses. The elemental analysis was in good agreement with the chemical formulas of the complexes. Qualitative reactions revealed the presence of sulphate, acetate, nitrate and chloride ions as counter ions. Solutions of their complexes react with barium chloride, ferric chloride, ferrous sulphate and silver nitrate giving a white precipitate of barium sulphate, red brown color of ferric acetate, black ring of FeSO4.NO and white precipitate of silver chloride indicating the existence of sulphate, acetate, nitrate and chloride in the ionic form. The data obtained from the molar conductivity and qualitative reactions showed that the complexes are electrolytes. The magnetic moments (B.M.) of the complexes were measured at room temperature. The complexes are found in diamagnetic character with molecular geometries octahedral except the magnetic susceptibility for Pd(II) complex is 3.24 B.M. with distorted octahedral geometry. The thermogravimetric and infrared spectroscopic data also confirm the presence of water in the composition of the complexes. The kinetic parameters of thermogravimetric (TGA) and its differential (DTG), such as activation energies, E*, enthalpies, ΔH*, entropies, ΔS* and Gibbs free energies, ΔG*, have been evaluated by using Coats-Redfern (CR) and Horowitz-Metzeger (HM) methods. The antimicrobial and anticancer activities have been evaluated in vitro.
Ofloxacin (HOfl) reacts with Zn(II), Zr(IV), Ce(III), Th(IV) and U(VI) in presence of NaOH and 2,2’-bipyridine (Bipy) and also, reacts with Zn(II), Zr(IV) and U(VI) in presence of 1,10-phenanthroline monohydrate (Phen) in ethanol and acetone as a solvents to form solid complexes. These complexes are nearly insoluble in common organic solvents but soluble in DMSO and DMF. The elemental analyses show that, all complexes have 1:1:1 stoichiometery. The magnetic moments (as B.M.) of the complexes were measured at room temperature. The complexes are found in diamagnetic character with molecular geometries octahedral except Ce(III) are found in paramagnetic character with measured magnetic moment value is 2.34 B.M. The spectroscopic data indicate that HOfl ligand found in deprotonated mode acting as bidentate ligand coordinated to the metal ions through pyridone oxygen and carboxylato oxygen. The thermal decomposition mechanisms proposed for HOfl, Bipy, Phen and their metal complexes were discussed. The kinetic parameters of the thermal decomposition reactions have been derived from thermogravimetric (TGA) and differential thermogravimetric (DTG) curves, using Coats-Redfern (CR) and Horowitz-Metzeger (HM) methods. Microbiological studies were carried out to compare the antibacterial and antifungal efficacy of the synthesized mixed ligand metal complexes with that of HOfl free ligand against Gram-negative and Gram-positive bacteria in addition to three species of fungi. The complexes as well as free ligands were tested for their in vitro cytotoxicity on human breast carcinoma cell line (MCF-7) and human colon carcinoma cell line (HCT-116).
Moxifloxacin hydrochloride (MOX) and Phen mixed ligand of Y(III), Zr(IV), Pd(II), La(III) and U(VI) complexes were synthesized as solids of a color characteristics of the metal ion in good yield. All of the complexes reported herein are hydrates with various degrees of hydration and air stable solids at room temperature. The analytical data are consistent with the proposed molecular formulas of complexes. The molar conductance values 144.30-277.80 S cm2 mol-1 for the complexes suggest that these are 1:2 and 1:3 electrolytes. Qualitative reactions revealed the presence of chloride, nitrate and acetate as counter ions, in good agreement with the molar conductivity measurements. The magnetic moments (as B.M.) of the complexes were measured at room temperature. The metal complexes are found in diamagnetic character and octahedral geometry around the metal ion but Pd(II) complex found in paramagnetism with measured magnetic moment value is 3.22 B.M. The complexes also characterized through IR, UV-Vis., 1H NMR, mass spectra as well as thermogravimetric analyses. The antibacterial activity of MOX, Phen, metal salts and metal complexes has been tested against four bacterial species such as E. coli, P. aeruginosa as Gram-negative and B. subtilis, S. aureus as Gram-positive. The antifungal activity has been tested against three species such as C. Albicans, A. awamori and Alternaria species. Also, the two ligands, in comparison to their metal complexes are screened for their anticancer activity against human breast carcinoma cell line (MCF-7 cells) and human colon carcinoma cell line (HCT-116 cells).