الفهرس 
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Abstract
The aim of this retrospective study is to prove or disprove whether there is a relationship between tumor thickness of oral cavity carcinomas and subsequent lymph node metastasis. This study was done in surgery department ,faculty of medicine , Menoufia University between April 2014and march 2015 after approval by the hospital ethics committees.It involved surgical resection of primary oral cavity carcinomas (tongue, alveolar margin and buccal mucosa) and neck dissection for 20 patient. Then all samples were pathologically investigated to determine the tumor thickness of the primary mass and the presence of lymph node metastasis. Following thorough clinical examination, routine pre-operative laboratory investigations and optimal radiological evaluation as ultrasonography (detect presence or absence of sonographically positive neck nodes, estimation of tumor thickness by intra-oral US.), CT neck &oral cavity ,sometimes M.R.I. and PET/CT scan if needed. Inclusion criteria includes Histopathologicaly proven oral cancer(oral squamous cell carcinoma), Clinical negative neck node, Stage I &II oral carcinoma, No previous cancer/radiotherapy/chemotherapy, Not operated before and good general condition allowing major surgical procedure. Exclusion criteria includes patients with stage III& IV oral cancer, lesion secondary to another primary site, patient performed excisional biopsy, patients with recurrent disease, patient with history of radiotherapy or chemotherapy for tumors in the head& neck.