الفهرس 
PRIMARY OSTEOARTHRITISOnly 14 pages are availabe for public view
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Abstract
Osteoarthritis (OA) is a late-onset musculoskeletal disease characterized by gradual thinning and loss of articular cartilage of the synovial joints with a concurrent alteration in the physiology of several other joint tissues, including the subchondral bone and the synovium (Loeser et al., 2012). Furthermore, OA is probably not a single disorder, but rather a group of overlapping distinct diseases. These diseases are the consequences of mechanical or biological events that destabilize the normal coupling of synthesis and degradation of extracellular matrix in articular cartilage and subchondral bone (Poole et al., 2001). The matrilin (MATNs) are a family of oligomeric extracellular matrix (ECM) proteins consisting at least of four related proteins (Mates et al., 2004). It has been found that enhanced matrilin-3 gene and protein expression was correlated with the extent of tissue damage in osteoarthritis patients. These findings suggest that tight regulation of matrilin-3 expression is essential for maintenance of the cartilage ECM microenvironment (Pullig, et al., 2002). The aim of this study was to evaluate the possible role of SNP6 polymorphism of MATN-3 gene in the development of osteoarthritis . This study included 50 subjects 5 males and 45 females, their ages ranged between 30-65 years. The studied subjects were divided into two groups, group I included 40 osteoarthritis patients (2 males and 38 females), with age ranged between 30-65 years and group II included 10 apparently healthy age and gender matched subjects as a control group (3 males, 7 females), their age ranged between 30- 65 years.