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Abstract Chapter one displays different publications concerning the complexation of thiosemi carbazides with a great attention to the compounds similar to that investigated and their biological activities. >The second chapter covers the experimental part and illustrates the experiments used in this work. It includes a list of reagents, stock solutions along with the physical measurements and instrumentation. The working procedures description for the preparation of the ligand and its metal complexes. In addition, this chapter includes the recommended procedures for the antibacterial and the antitumor activity of the prepared metal complexes .Chapter three deals with the results and discussion which are summarized to give the following information:h the stoichiometries concluded from their analytical data of carbon, hydrogen, nitrogen, sulfur, chloride and metal contents.Most of complexes have high melting points (>300˚C) and insoluble in most organic solvents.3-The coordination sites of the ligand, the nature of metal-ligand bonds and the nature of the acetate groups and the existence of the solvated molecules have been elucidated using IR spectra. Different modes of chelation for the investigated ligands are suggested based on careful comparison between the spectra of the ligands and their corresponding complexes.We study the biological activity of the complexes as antibacterial, antioxidant, antitumor and also the toxicity effect of it on rats. |