الفهرس 
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Abstract
Aflatoxin B1 is considered as a feed borne-immunosuppressive mycotoxin. Nanotechnology is a powerful new technology for reconstructing nature at the atomic and molecular level. This study was conducted to determine the efficacy of nano-composite Magnesium Oxide and Silicon Oxide (MgO-SiO2) to reduce the toxic effects of aflatoxin B1 (AFB1) on the immunity and fertility of adult male rats for 8 weeks. Animals were divided into a control and three experimental groups (25 each). The first experimental group received feed contained 200 ppb AFB1. The second group received feed contained 200ppb AFB1/kg and 0.5 g/kg nano-composite of MgO-SiO2. Rats of the third experimental group received 0.5 g/kg nano-composite of MgO-SiO2. Result showed that AFB1 markedly reduced body weight gain and food and water consumption and also induced pathologic changes in the liver, spleen gastrointestinal tract and testis as showed on postmortem inspection and histopathological examination. Cellular immune response (as determined by assessment of total and differential leucocytic count, the phagocytic activity of neutrophils, lymphocytes transformation, macrophages activity and serum lysozyme activity) and humoral immune response (as assessed by the measurement of the serum total protein and its fractions as estimated by SDS- PAGE electrophoresis) were severely reduced by AFB1. In addition, fertility (as estimated by the level of serum testosterone and the percent of DNA breaks in the testis) was decreased by AFB1. Residual AFB1 in serum, liver and stool showed significant increase. On the other hand, all these deleterious effects of AFB1 were alleviated in the group that received feed contain AFB1 and nano-composite MgO-SiO2. These findings suggested that nano-composite MgO-SiO2 has high affinity to adsorb AFB1 and can effectively modulate its toxicity in rats and may offer a novel approach to the preventive management of aflatoxicosis in animals.