الفهرس 
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Abstract
The aim of the present study was to investigate the possible hepatoprotective and treatment effects of Portulaca oleracea (P.o) extract against CCl4-induced hepatic toxicity in adult male albino rats. The study was carried on adult male albino rats (150-170g). The rats were randomly divided into 8 groups (6 rats for each group) according to the following design : Group1 (normal control). group 2 (CCl4-treated rats) received only CCl4. group 3 treated with silymarin only. group 4 treated with Portulaca oleracea alone. group 5 received (silymarin+CCl4) as a protective standard group. group 6 received (CCl4+silymarin) as a curative standard group. group 7 received (p.o+CCl4) as a protective purslane group. group 8 received (CCl4+P.o) as a protective purslane group. The following results were obtained : 1. There was a highly significant elevation in serum of AST, ALT, GGT, bilirubin, ALP, and globulin while, a significant decrease in albumin level and no a significant change in total protein level in rats treated with CCl4 as compared to normal control rats. Rats treated with silymarin or Portulaca oleracea before and after CCl4 treated ameliorated liver functions (the above parameters) as compared to CCl4 - treated rats. 2. The concentrations of creatinine, urea and uric acid were significantly decreased in rats treated with silymarin or Portulaca oleracea before, after CCl4 treated when compared to CCl4 - treated rats. 3. There was a highly significant increased GSH, SOD and CAT activities while the level of MDA was decreased in rats treated with Portulaca oleracea or silymarin before and after CCl4 administration when compared to CCl4- treated rats. 4. No changes were detected in Hematological parameters (Hb,RBCs,WBCs, PCV% and platelets) compared to CCl4-treated rats. 5. Improvement in histopathological examinations of the liver sections in rats received ethanolic extract of Portulaca oleracea or silymarin before or after treated with CCl4. 6. By Gas chromatography-mass spectrometry (GC-MS) analysis, presence many components that provides an evidence for the hepatoprotective effect and antioxidant capacity of purslane.