الفهرس 
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Abstract
The study included fifty six infertil oligoasthenotertatozoospermic (OAT) male patients presenting to the Andrology & STDs Department, Faculty of Medicine, Cairo University.
Exclusion criteria were; smoking, leucocytospermia and hormonal therapy.
They were subjected to:
1- Complete history taking:
2- Clinical examination.
3- Semen analysis according to WHO (2010) guidelines.
4- Estimation of seminal GPx and MDA.
5- Estimation of HO-1 enzyme activity in the ISV during high ligation varicocelectomy as well as from antecubital vein representing the peripheral venous circulation.
The results were as follows:
1. The mean levels of HO-1 enzyme activity in the ISV demonstrated significant decrease compared with the peripheral venous circulation.
2. There was significant positive correlation between ISV HO-1 enzyme activity and sperm concentration, sperm motility, sperm normal morphology and seminal GPx enzyme levels.
3. There was significant negative correlation between ISV HO-1 enzyme activity and seminal MDA levels.
4. There was nonsignificant correlation between ISV HO-1 enzyme activity and HO-1 enzyme activity in the peripheral venous circulation.
5. There was significant decrease in the mean levels of ISV HO-1 enzyme activity in Vx grade III cases compared with Vx grade II cases and in bilateral Vx cases compared with unilateral Vx cases.