الفهرس 
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Abstract
Investigation of water quality used in different broiler farms (82 farm) showed increase in some water chemical parameters which associated with sorts of vaccination failure with low antibody titer leading to recurrence of infection .Failure in disinfection as tool of biosecurity program associated bad water quality. Two experiments are conducted to evaluate the impact of water quality on bird immune response against NDV and IB field vaccination and broiler performance indices. Effect of water chemicals on antibacterial activity of selected commercial used disinfectants was determined. NDV vaccine using PBS at 2 weeks old induced highest antibody titer while at 5th week both NS 0.09% and PBS potentiate higher immune response Vs. water with high and low levels of organic matter ( COD). High and low levels of hard water, ammonia, nitrite and chloride affected negatively antibodies production to NDV vaccination at 2 weeks old. Both NS 0.09% and PBS used during vaccination potentiate higher immune response to NDV. Water used for vaccination of IBV with high and low levels of COD, hardness, ammonia, nitrite, chloride, sulphate and phosphate decreased antibody titer from 2nd to 5th week. The highest antibody titers are recorded with use of TW-DSM and DW during vaccination at 2nd week, where PBS only potentiate more antibody response at 5th week . Water with high and low levels of selected chemicals decreased significantly all somatic indices when used for vaccination with NDV, IBV with regard to highest somatic indices which reported for bursa and thymus with use of PBS. Water with high and low levels of selected chemicals (COD, hardness, ammonia, nitrites, phosphate) decreased significantly T.P, globulins and increased A/G ratio compared to all control groups. Highest globulins and lowest A/G ratio attained with use of TW-DSM and PBS. Water high and low chloride, ammonia, nitrite, sulphate and low pH value used induced decreased W/F ratio, dressing % and PI but increased both of carcass dressing % and performance index. Water with high and low Phosphate, high pH concentration increased W/F ratio but decreased both dressing % and PI. It’s recommended to use TW and PBS during vaccination and avoid use water with high levels of chloride, ammonia, nitrite, sulphate, phosphate and pH to avoid the reduction in PI from socioeconomic point. After 10 minutes contact time, water with high hardness, ammonia, nitrite, sulphate, phosphate used for disinfection reduced bacterial activity with highest log 10 reduction when use peraclean TH4 Virkon-SProphyl Iodine in order. Except chloride peraclean TH4 Virkon-S Iodine Prophyl in order.