الفهرس 
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Abstract
Lipid profile is a pattern of lipids in the blood which usually includes the levels of total cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides (TG), very low density lipoprotein (VLDL) cholesterol and the calculated low-density lipoprotein (LDL) cholesterol.
Liver plays an essential role in lipid metabolism, several stages of lipid synthesis and transportation. Therefore, it is reasonable to expect an abnormal lipid profile in those with severe liver dysfunction.
Derangement of serum lipid profile is a common observation in patients with chronic liver diseases
The aim of the study was to determine changes in the lipid profile in patients with HCV-related liver cirrhosis and to determine if it correlates with the severity of liver damage.
This study was a hospital-based prospective cross sectional one. The study was carried out on patients with liver cirrhosis admitted to Tropical Medicine and Gastroenterology Department, Minia University Hospital during period from 2013 to 2014.
The study included 80 patients with HCV-related liver cirrhosis (40 patients with DM and another 40 patients without DM) and forty subjects were taken as controls.
*each one of these patients and controls were subjected to:
-History taking.
-Clinical examination.
-Ultrasonography
-Child-Turcotte Pugh criteria
-Laboratory investigations including fasting lipid profile.
We concluded that:
-Lipid profile decreases in patients with liver cirrhosis.
-As the liver disease progresses, the lipid profile shows marked decline in its variables especially serum VLDL.
- Serum HDL decreases significantly in cirrhotic patients with HCC compared to cirrhotic patients without HCC.