الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
This study aimed to : This study was planned to study the increased coagulation and platelet activation in children with β-thalassemia, to analyze the possible factors that lead to hypercoagulable state in children with β-thalassemia and to study the PH in conjunction with the platelet activation and the hypercoagulable state in children with β-thalassemia. The study was settled in MUCH in compliance with Clinical Pathology department ; faculty of Medicine Mansoura University; from September 2013 till March 2015. Thirty six Egyptian children with β-TM [44.4% males, 55.6% female] with mean age of 9.9 years [±4.7 SD], were included in our study. In addition, 20 age and sex matched healthy Egyptian children were enrolled as control. Patients were recruited from the hematology OPC in MUCH. Healthy children were selected as controls from those who are attending the MUCH OPC for routine follow-up care with no known history of chronic systemic illness, blood diseases or BT. The diagnosis of patients were done through HPLC/electrophoresis which shows Hgb-F constituting the 92- 95% of the total Hgb [Jha and Jha, 2014]. Those who were receiving BT ≥ 12 times/year were considered frequently transfused. On the other hand, those who were receiving BT less than 12 times/year were considered infrequent transfused [Hassan et al., 2010]. Six out of our patients [16.7%] were not receiving any iron chelators through their course of illness. On the other hand, 30 of our patients received iron chelators with a percentage of [83.3%]. Twenty two [61.1%] out of our patients underwent splenectomy 3 to 15years prior to the study. The results of this study revealed that, patients with β-TM were having significantly higher P.selectin level, lower PC and AT-III in comparison to the control group, indicative of the presence of platelet activation and hypercoagulable state among the thalassemic patients. Such platelet activation and hypercoagulable state were evident among the splenectomized patients in comparison to the non-splenectomized patients. On assessing the status of the BT in relation to the platelet activation and hypercoagulable state, those who were frequently transfused had less liability to such platelet activation and hypercoagulable state.