الفهرس 
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Abstract
The aim of this work was to study the role of chromosomal abnormalities and AZF genes microdeletion in a group of Egyptian infertile men with azoospermia and severe oligospermia and their prognostic value.The present study was carried out on 193 Egyptian infertile men. On the basis of their semen analysis; 112 patients with azoospermia and 81 patients with severe oligospermia compared to 20 fertile men as controls. For each patient the following was done; history taking, clinical examination; both general and local genital with special care to the testicular size, seminal analysis, chromosome analysis (karyotyping) and AZF gene study by Polymerase chain reaction (PCR) for the Y chromosome, they included the AZFa, AZFb and AZFc regions. The study showed the following results: chromosomal abnormalities were found in 25 cases (13%) of infertile men The frequency of chromosomal abnormality was (17.9%) in men with azoospermia which is significantly (P=0.017) higher than that in men with severe oligospermia (6.2%). Y chromosome microdeletions were found in 16 cases (8.3%) of infertile males. The frequency of AZF microdeletion was 11.6% in men with azoospermia which is significantly (P=0.049) higher than that in men with severe oligospermia (3.7%).