الفهرس 
from aryl nitrileOnly 14 pages are availabe for public view
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Abstract
A mixture of quinazolin-4-ol (1) and thionyl chloride was refluxed followed
by treating with sodium azide in dry DMF to afford 2 was formed in 95% yield
(Scheme 1).
Triphenyl phosphine and azide derivative 2 were dissolved in pyridine and
kept at room temperature for 1 h to afford 3 in 98% (Scheme 1).
The phosphinimine 3 in pyridine and concentrated ammonium hydroxide
afforded the corresponding amine 4 in 80% (Scheme 1). A solution of 4, diethyl malonate, diethyl 2-methylmalonate, diethyl 2-
ethylmalonate, diethyl 2-butylmalonate, and/or diethyl 2-phenylmalonate, and
diphenyl ether were refluxed for 1 h. Diethyl ether was added with strong stirring
and the products were collected by filtration to afford 5-9 in 53-72% yields
(Scheme 2).