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Abstract The present study was conducted to evaluate the effect of rapid distraction rate on the quality and quantity of mandibular new bone regenerate following DO in goats. The rapid distraction rate was 2 mm/day. The study was conducted on 14 goat. The animals were divided to two equal groups. Group I (Study group), the distraction rate was 2 mm/day for five days. Group II (Control group), the distraction rate was 1mm/day for 10 days. The regenerated bone in this study was evaluated by clinical examination, macroscopic examination, radiographic assessment and histological evaluation. Clinical examination of the animals was used to assess mandibular deviation after the distraction period. Macroscopic examination was performed by 3D measurements of the sample. These measurements may assist to compare the total bone thickness among the two groups. Radiographic evaluation of the samples was done through scanning by CBCT. CBCT was suggested as reliable volumetric quantitative parameter to evaluate bone density by using Hounsfield unit during bone healing and correlates significantly with histological findings. Histological examination of the newly regenerate bone was the comprehensive evaluation. Haematoxylin and Eosin slides, Masson Trichrome slides and morphometric evaluations were used to allow the assessment of many parameters related to numerical, dimensional and geometrical object features. The bone quality was evaluated by histological assessment of the distracted gap, while the bone quantity was evaluated through computerized histomorphometry. Image analyzing system was used to calculate area of osteoid percentage, cortical and trabecular bone thickness. |