الفهرس 
• PathogenesisOnly 14 pages are availabe for public view
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Abstract
Hepatitis C virus (HCV) is considered to be the leading cause of liver disease in human. The poor survival after diagnosis has led to the introduction of screening programs and ultrasound scanning. Unfortunately, the results of programs are still unsatisfactory. Hence there is a need for powerful markers for early diagnosis. This study was conducted on two groups of patients admitted to Mansoura University Hospitals, thirty one of them were cirrhotic patients, and the thirty seven were suffering from hepatocellular carcinoma (HCC). In addition to 20 healthy subjects were selected as control group being without past history of liver disease and their age range was (26–60) and seventeen of them were female and the other three were male. The following investigations were performed to study the following parameters: a- Full clinical history and examination : b-Biochemical investigation : The results revealed the following findings: I-In the hepatic cirrhosis group 1.serum albumin , serum bilirubin : There was a significant decrease in serum bilirubin versus health subjects. 2.liver enzyme tests : There was a significant increases in serum Aspartate aminotransferase (AST) (u/l), Alanine aminotransferase (ALT) (u/l) and Alkaline phosphatase (ALP) (KAU). 3.serum prothrombin time : There was a significant increases in serum (PT) (second) versus control. 4.Serum Alphafetoprotein and ferritin : There was a significant increase in serum Alpha-fetoprotein (AFP) (ng/ml) and serum Ferritine (ng/ml) II-In hepatocellular carcinoma group 1.serum Albumin : A significant decrease in serum albumin (gm/dl) comparable to the cirrhotic and healthy groups. 2.serum bilirubin : There was a significant decrease in serum bilirubin (mg/dl) versus healthy subjects and non significant increase versus cirrhotic patients. 3.liver enzyme tests: Liver enzyme activities showed a significant increases in (ALP) (K.A.U) versus healthy subjects and cirrhotic patients and (AST), (ALT) (u/l) increases significant versus healthy subjects but decreased non-significant versus cirrhotic patients. 4.Serum prothrombin time : There was a significant increase versus control subjects but a non significant increase versus cirrhotic patients. 5. Serum AFP and Ferritin : There was a significant increase in AFP versus control subjects and cirrhotic patients while Ferritin increased significant versus control but non significant versus cirrhotic patients.