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Abstract The kidneys are located in the retroperitoneal space on either side of the vertebral column, or the spine. The retroperitoneal space is the cavity behind the abdominal cavity, which is the part of the body where the abdominal organs such as the liver, spleen, and bowel are located. The right kidney is located behind the lower portion of the liver. The left kidney is adjacent to the spleen and is often slightly higher than the right kidney .Function of Kidney The kidneys allow consumption of a variety of foods, drugs, vitamins and supplements, additives, and excess fluids without worry that toxic by-products will build up to harmful levels. The kidney also plays a major role in regulating levels of various minerals such as calcium, sodium, and potassium in the blood. As the first step in filtration, blood is delivered into the glomeruli by microscopic leaky blood vessels called capillaries. Here, blood is filtered of waste products and fluids while red blood cells, proteins, and large molecules are retained in the capillaries. In addition to wastes, some useful substances are also filtered out. The filtrate collects in a sac called Bowman’s capsule. The tubules are the next step in the filtration process. The tubules are lined with highly functional cells which process the filtrate, reabsorbing water and chemicals useful to the body while secreting some additional waste products into the tubule. Reported that the kidneys also produce certain hormones that have important function in the body, including the following:Active form of vitamin D (calcitriol or 1.25 dihydroxyvitamin D), which regulates absorption of calcium and phosphorus from foods, promoting formation of strong bone. Erythropoietin (EPO), which stimulates the bone marrow to produce red blood cells. Rennin, which regulates blood volume and blood pressure. Uses of Moringa oleifera plant the moringa plant is a multipurpose plant and has been used and consumed by humans. in his review of the medical evidence for its nutritional, therapeutic, and prophylactic properties states many benefits of the plant. The Moringa trees have been used to combat malnutrition, especially among infants and nursing mothers. Leaves can be eaten fresh, cooked, or stored as dried powder for many months without refrigeration, and reportedly without loss of nutritional value It is especially promising as food source in the tropics because the tree is in full leaf at the end of the dry season when other foods are typically scarce. The following medicinal uses have been observed from the use of various parts of the plant. The leaves have anthelmintic, aphrodisiac properties and cures hallucinations, hiccough and asthma. The fruit are used to diseases and head complaints. The oil is useful in leprous ulcers and as external application for rheumatism. The roots and seeds are prescribed for the treatment of snakebites and scorpion stings. The roots have laxative, expectorant, diuretic properties and good for treating inflammations, sore throat, bronchitis, piles, stomatitis, urinary discharges and obstinate asthma. The root bark is useful in treating heart complaints, eye diseases, inflammation, dyspepsia, and enlargement of spleen. The root and bark have abortifacient effect. In the tropics reported that there are thirteen species of moringa trees in the family moringaceae and that Moringa oleifera is the most widely cultivated species. This study aimed to investigate the effect of some leaves Moringa on the kidney failure rats induced by gentamicin. Thirty adult male albino rats, weighing 150-160g were divided into Six groups each with five rats. One of them was Negative Control Group which fed on standard diet and tab water, and the other group was fed on standard diet + 0.10 mg\kg body weight by gentamicin 6 days to induce the kidney failure . This group was further divided into the following subgroups:- Group2: kidney failure 25 RATS In this group, rats were induced kidney failure by intra-peritoneal injection of gentamicin (aminoglycosides antibiotics) to induce kidney failure. This group was subdivided into 5 subgroups to fed on the experimental diets for (4) weeks according to the following: Group (a): 5rats: positive control group (untreated group) Group (b): 5rats: treated with 3% moringa leaves powder. Group (c): 5rats: treated with 5%moringa leaves powder. Group (d): 5rats: treated with 7% moringa leaves powder. Group (e): 5rats: treated with 9%moringa leaves powder. At the end of experiment (4 weeks), the blood samples were collected after 12 hours fasting and serum was separated for determination of urea, creatinin, uric acid, glotamic oxaloacetic transaminas (G.O.T), glotamic pyruvic transaminas (G.P.T), and alkaline Albumin(A.L.P). Lipid profile Cholesterol, tri glycerides (T.G),(LDL),(HDL),(VLDL),heaemoglobin,heamatocrit,(R.B.C) ,(W.B.Cs),platelet. At the same time, the organs: heart, kidney, liver, spleen and lungs were removed, washed in salin solution, dried by filter paper, weighted, and stored frozen in formalin solution 10% for histopathological examinations. |